Selective Impairment of Working Memory in a Mouse Model of Chronic Cerebral Hypoperfusion
نویسندگان
چکیده
منابع مشابه
Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion.
BACKGROUND AND PURPOSE We recently designed a mouse model of chronic cerebral hypoperfusion, in which the cerebral white matter is damaged without significant gray matter lesions. The behavioral characteristics of these mice were studied using a test battery for neurological and cognitive functions. METHODS Adult C57Bl/6 male mice were subjected to either sham-operation or bilateral common ca...
متن کامل(-)-SCR1693 Protects against Memory Impairment and Hippocampal Damage in a Chronic Cerebral Hypoperfusion Rat Model
Chronic cerebral hypoperfusion (CCH) is one of the most common causes of vascular dementia (VaD) and is recognised as an etiological factor in the development of Alzheimer's disease (AD). CCH can induce severe cognitive deficits, as assessed by the water maze task, along with neuronal loss in the hippocampus. However, there are currently no effective, approved pharmacological treatments availab...
متن کاملSynergistic memory impairment through the interaction of chronic cerebral hypoperfusion and amlyloid toxicity in a rat model.
BACKGROUND AND PURPOSE Vascular pathology and Alzheimer disease (AD) pathology have been shown to coexist in the brains of dementia patients. We investigated how cognitive impairment could be exacerbated in a rat model of combined injury through the interaction of chronic cerebral hypoperfusion and amyloid beta (Aβ) toxicity. METHODS In Wistar rats, chronic cerebral hypoperfusion was modeled ...
متن کاملCiticoline Protects Against Cognitive Impairment in a Rat Model of Chronic Cerebral Hypoperfusion
BACKGROUND AND PURPOSE Cerebral white matter (WM) lesions are frequently observed in human cerebrovascular diseases, and are believed to be responsible for cognitive impairment. Various neuroprotective agents can suppress this type of WM or neuronal damage. In this study, we investigated whether citicoline, a drug used to treat acute ischemic stroke, can attenuate WM lesions and cognitive decli...
متن کاملERRATUM: Citicoline Protects Against Cognitive Impairment in a Rat Model of Chronic Cerebral Hypoperfusion
[This corrects the article on p. 33 in vol. 5, PMID: 19513332.].
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ژورنال
عنوان ژورنال: Stroke
سال: 2007
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.107.490151